University of California, San Diego・Stephen M Hedrick。R1 ES細胞を用いて作出。RBRC01891： C57BL/6Jへ戻し交配された（N8以上）、RBRC01892：C57BL/6Jへ8回戻し交配された後、BALB/cへ戻し交配された（6回以上）。 The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. Mgl1 (Clec10a) 遺伝子のノックアウトマウス。MGLは内在性糖鎖認識タンパク分子であるカルシウム依存型 (C型) レクチンのひとつ。エクソン2と3をネオマイシン耐性遺伝子で置換したもの。C57BL/6背景 (RBRC01891) およびBALB/c背景 (RBRC01892) 。C57BL/6背景では、赤血球数の増加が認められる (BALB/c背景では未検証) 。ホモマウスは生存性、妊性有り。エクソン2から10までをネオマイシン耐性遺伝子とβガラクトシダーゼ遺伝子で置換したものあり (RBRC01889およびRBRC01890) 。 Homozygote x Homozygote [or Crossing to BALB/cAnNCrlCrlj] Homozygote x Homozygote [or Crossing to BALB/cAnNCrlCrlj] 入村　達郎 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>リソースの利用にあたっては、寄託者との共同研究とする。 D (more than 6 months) C.B6(129)-Clec10a<tm1Hed>/TatsRbrc Tatsuro IRIMURA R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] <a href='https://brc.riken.jp/mus/pcr01892'>Genotyping protocol -PCR-</a> mMgl1 knockout mice (BALB/c) RBRC01892 Mgl1 gene knockout mice. Exons 2 and 3 were replaced with a PGK-neo cassette. The MGL is one of the calcium-dependent (C type) lectins, which are intrinsic carbohydrate recognition proteins. C57BL/6 background (RBRC01891) and BALB/c mixed background (RBRC01892). Homozygous mutant mice were viable and fertile. mMgl1 knockout mice (BALB/c) mMgl1 knockout mice (BALB/c) true Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.juntendo.ac.jp/graduate/laboratory/labo/glyco/" target="_blank">Lab HP</A> Univ. Tokyo 国立大学法人東京大学 D（6か月以上） mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, bovine growth hormone poly A, mouse Clec10a genomic DNA Developed by Stephen M Hedrick, University of California. R1 ES cells were used to generate the knockout mice. R RBRC01891: backcrossed to C57BL/6J over 8 times. RBRC01892: backcrossed to C57BL/6J for 8 times, and then backcrossed to BALB/c over 6 times.